Marketing & SocialMCP Registrypypi5 toolsB · 76

DeepDNA local MCP server

ai.deepdna · Updated today

Reads a raw DNA file on your computer and reports the variants DeepDNA curates, with sources.

At a glance

DeepDNA local is an MCP server in the Marketing & Social category. It runs locally over stdio via `uvx deepdna-mcp`, and declares no required credentials. It exposes 5 tools, including list_genes, lookup_gene and lookup_variant. It scores B (76/100) on the MCP Skills Hub health score as of Oct 28, 2026.

Source 0

One-click install

VS Code VS Code Insiders Cursor

Opens your editor and pre-fills the config. Your editor will ask before adding it.

How to install DeepDNA local in your AI client

Setup for Claude Code, Claude Desktop, Cursor, Codex, Windsurf, Cline and VS Code — copy-paste ready.

How to install DeepDNA local in Claude CodeAnthropic's agentic CLI

1
Add the server
bash
```
claude mcp add local -- uvx deepdna-mcp
```
2
Verify it's connected
bash
```
claude mcp list
```
Sharing it with your team?
Add `--scope project` to write it to .mcp.json in the repository root, which you can commit (with the secrets left as environment variables).
Use it in a session
Ask Claude to use the tools this server exposes (e.g. list_genes, lookup_gene, lookup_variant). It discovers them automatically.

How to install DeepDNA local in Claude DesktopDesktop app (MCP config)

Open your MCP config
macOS: ~/Library/Application Support/Claude/claude_desktop_config.json · Windows: %APPDATA%\Claude\claude_desktop_config.json

Add this server

json

{
  "mcpServers": {
    "local": {
      "command": "uvx",
      "args": [
        "deepdna-mcp"
      ]
    }
  }
}

Restart Claude Desktop
The tools appear under the 🔌 menu once the app reloads.

How to install DeepDNA local in CursorAI-first code editor

Create / edit .cursor/mcp.json in your project

json

{
  "mcpServers": {
    "local": {
      "command": "uvx",
      "args": [
        "deepdna-mcp"
      ]
    }
  }
}

Enable it
Cursor Settings → MCP → toggle the server on. Tools become available to the Composer/Agent.

How to install DeepDNA local in Codex CLIOpenAI coding agent

Add to ~/.codex/config.toml

toml

[mcp_servers.local]
command = "uvx"
args = ["deepdna-mcp"]

Run Codex
Codex loads MCP servers from config.toml on startup and exposes their tools to the agent.

How to install DeepDNA local in WindsurfCodeium's agentic IDE

Edit ~/.codeium/windsurf/mcp_config.json

json

{
  "mcpServers": {
    "local": {
      "command": "uvx",
      "args": [
        "deepdna-mcp"
      ]
    }
  }
}

Reload
Windsurf → Cascade → refresh MCP servers. Cascade can now call the tools.

How to install DeepDNA local in ClineVS Code autonomous agent

Open Cline → MCP Servers → Configure
Adds to cline_mcp_settings.json.

Add the server

json

{
  "mcpServers": {
    "local": {
      "command": "uvx",
      "args": [
        "deepdna-mcp"
      ]
    }
  }
}

How to install DeepDNA local in VS CodeCopilot / MCP support

Create .vscode/mcp.json

json

{
  "servers": {
    "local": {
      "type": "stdio",
      "command": "uvx",
      "args": [
        "deepdna-mcp"
      ]
    }
  }
}

Start it
VS Code shows a ▶ Start action above the server entry. Agent mode (Copilot Chat) can then use the tools.

What tools does DeepDNA local expose? (5)

Taken from the project's README — the server itself was not queried, so check its docs for the exact schemas.

list_genesThe genes in the knowledge base, with a one-line summary and category for each
lookup_geneEverything curated about one gene: function, key variants with rsIDs, phenotypes, drug interactions, what a consumer genotyping array can and cannot tell you, and sources
lookup_variantOne variant by dbSNP rsID: gene, star-allele or common name, alleles on the plus strand of GRCh37, effect, frequency note and sources. Takes the rsID only, never a genotype
lookup_drug_geneGuidance for a gene, optionally for one drug: guideline (CPIC or DPWG where one exists), summary, phenotype groups and sources
check_medicationsSplits a list of generic drug names into drugs with a curated record (gene, and a `basis` field: CPIC or DPWG guideline, drug label, or primary literature) and drugs not covered. Needs no genotype

What the code can do

Source analysis currently covers npm packages only. This server ships as a Python package, which needs a different parser.

Before you install

Signals gathered from the source repo and package registry — not a safety verdict.

What it can reach

Runs code on your machine — Executes as a local process with your user's permissions, including filesystem access.
Downloads at launch — The package is fetched from its registry each run unless you pin a version.

Last commit today — Actively maintained.
Repository created 17 days ago — Very new project with little track record yet.
0 GitHub stars — Very little community usage so far.

Client compatibility

Claude Code: NativeClaude Desktop: NativeCursor: NativeCodex CLI: NativeWindsurf: NativeCline: NativeVS Code: Native

Health score

B · 76

Maintenance, adoption, transparency and packaging — not a safety audit. How this is calculated

Maintenance30%100%
Last commit 0 days ago.
Adoption20%0%
0 stars.
Transparency20%100%
4/4: ✓ public source repo, ✓ declared license, ✓ documentation, ✓ discoverable tool list.
Provenance15%75%
Links to its own repository; package linkage unverified.
Packaging15%100%
Publishes a pinned version (0.1.2).

Documentation

Full README

DeepDNA MCP server

A remote Model Context Protocol server that gives AI agents cited pharmacogenomic and gene-variant lookups, so answers can quote CPIC and DPWG guidance and its sources. This repository also holds a local package that reads a raw DNA file on the user's own computer; nothing from the file is sent to DeepDNA, but what the package reports becomes part of the conversation with the AI model.

text

https://deepdna.ai/mcp

Streamable HTTP, stateless, no API key, no account. Listed in the official MCP registry as ai.deepdna/knowledge.

Educational information only, not medical advice. The server reports what curated sources and guidelines say about a gene, a variant or a drug–gene pair. It does not diagnose, prescribe or recommend a dose.

Tools

| Tool | What it returns | |---|---| | list_genes | The genes in the knowledge base, with a one-line summary and category for each | | lookup_gene | Everything curated about one gene: function, key variants with rsIDs, phenotypes, drug interactions, what a consumer genotyping array can and cannot tell you, and sources | | lookup_variant | One variant by dbSNP rsID: gene, star-allele or common name, alleles on the plus strand of GRCh37, effect, frequency note and sources. Takes the rsID only, never a genotype | | lookup_drug_gene | Guidance for a gene, optionally for one drug: guideline (CPIC or DPWG where one exists), summary, phenotype groups and sources | | check_medications | Splits a list of generic drug names into drugs with a curated record (gene, and a basis field: CPIC or DPWG guideline, drug label, or primary literature) and drugs not covered. Needs no genotype |

All five tools are read-only.

Two prompts, medication_review and explain_variant, package the common questions for clients that show MCP prompts.

Coverage today is 12 genes: CYP2C19, CYP2C9, CYP2D6, SLCO1B1, VKORC1, UGT1A1, G6PD, MTHFR, COMT, HFE, APOE and BRCA1, with 51 curated drug–gene pairs across 11 of them: 40 cite a CPIC or DPWG guideline, the rest a drug label or the primary literature; the basis field in check_medications says which (guideline is null, or "drug label", when no guideline exists). It is a small, reviewed set, not a mirror of PharmGKB/ClinPGx. Every record lists its sources. The level field (the guideline's evidence grade) is null for every pair today.

Connect

Claude Code

bash

claude mcp add --transport http deepdna https://deepdna.ai/mcp

Cursor (~/.cursor/mcp.json) and other clients that use an mcpServers file:

Excerpt — the full document is on GitHub.

Alternatives to DeepDNA local

DeepDNAB · 73Pharmacogenomics for AI agents: cited drug–gene, gene and rsID lookups plus a medication screen.

Maintain DeepDNA local? Add a badge to your README

Shows its health grade, and links readers to install steps for every client.

markdown

[![DeepDNA local on MCP Skills Hub](https://mcp-skills-hub.vercel.app/badge/ai-deepdna-local)](https://mcp-skills-hub.vercel.app/mcps/ai-deepdna-local)

Catalog data refreshed Oct 28, 2026. Something wrong? Report it.